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HelpTest ID SAL Hypersensitivity Pneumonitis IgG Antibodies, Serum
Useful For
Evaluation of patients suspected of having hypersensitivity pneumonitis induced by exposure to Aspergillus fumigatus, Thermoactinomyces vulgaris, or Micropolyspora faeni
Method Name
Fluorescence Enzyme Immunoassay (FEIA)
Reporting Name
Hypersensitivity Pneum IgG Ab, SSpecimen Type
SerumContainer/Tube:
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 0.5 mL
Specimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 21 days |
| Frozen | 21 days |
Clinical Information
Hypersensitivity pneumonitis (HP) is a heterogeneous disease caused by exposure to organic dust antigens, animal proteins, chemicals, medications, or microorganisms (eg, Thermoactinomyces vulgaris, Micropolyspora faeni, Aspergillus fumigatus). The immunopathogenesis of disease is not known; but, several immunologic mechanisms may play a role in producing alveolitis, including cellular immunity mediated by CD4 and CD8 T lymphocytes, immune-complex mediated inflammation, complement activation or activation of alveolar macrophages.(1)
HP is suspected clinically in patients who present with intermittent or progressive pulmonary symptoms and interstitial lung disease. The diagnosis is established by compatible clinical and radiographic findings, pulmonary function tests, and demonstration of specific antibodies to organic antigens known to cause the disease.
Reference Values
Aspergillus fumigatus, IgG ANTIBODIES
<4 years: not established
≥4 years: ≤102 mg/L
Micropolyspora faeni, IgG ANTIBODIES
0-12 years: ≤4.9 mg/L
13-18 years: ≤9.1 mg/L
>18 years: ≤13.2 mg/L
Thermoactinomyces vulgaris, IgG ANTIBODIES
0-12 years: ≤6.6 mg/L
13-18 years: ≤11.0 mg/L
>18 years: ≤23.9 mg/L
Cautions
IgG antibodies to Aspergillus fumigatus, Thermoactinomyces vulgaris, or Micropolyspora faeni may be found in sera from healthy individuals; the presence of these specific antibodies is not sufficient to establish the diagnosis of hypersensitivity pneumonitis (HP).
Elevated concentration of antibodies to Aspergillus fumigatus may be also found in patients with invasive aspergillosis and cavitary lung disease.(2)
The concentrations of antibodies to these antigens may decrease following treatment, although elevated concentrations may persist in treated patients.
Day(s) Performed
Monday through Friday
Report Available
Same day/1 dayPerforming Laboratory
Mayo Medical Laboratories in Rochester
CPT Code Information
86606-Aspergillus fumigatus
86609 x 2-bacterium, not elsewhere specified