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Test ID SASP Aspergillus fumigatus, IgG Antibodies, Serum

Useful For

Evaluation of patients suspected of having lung disease caused by Aspergillus fumigatus

Method Name

Fluorescence Enzyme Immunoassay (FEIA)

Reporting Name

Aspergillus fumigatus, IgG Ab, S

Specimen Type

Serum

Container/Tube: 

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Clinical Information

Aspergillus fumigatus is one of the causative agents of hypersensitivity pneumonitis (HP), as well as invasive lung disease with cavitation or pneumonitis and allergic bronchopulmonary disease.(1) Other causative microorganisms of HP include Micropolyspora faeni and Thermoactinomyces vulgaris. The development of HP and allergic bronchopulmonary disease caused by Aspergillus fumigatus is accompanied by an immune response to Aspergillus fumigatus antigens with production of IgG or IgE antibodies, respectively. While the immunopathogenesis of HP and allergic bronchopulmonary disease is not known, several immune mechanisms are postulated to play a role, including both cellular and humoral mechanisms.

Reference Values

<4 years: not established

≥4 years: ≤102 mg/L

Cautions

IgG antibodies to Aspergillus fumigatus, Thermoactinomyces vulgaris, or Micropolyspora faeni may be found in sera from healthy individuals; the presence of these specific antibodies is not sufficient to establish the diagnosis of hypersensitivity pneumonitis (HP).

 

Elevated concentration of antibodies to Aspergillus fumigatus may be also found in patients with invasive aspergillosis and cavitary lung disease.

 

The concentrations of antibodies to these antigens may decrease following treatment, although elevated concentrations may persist in treated patients.

Day(s) Performed

Monday through Friday: 4 p.m., Saturday; 9 a.m.-3 p.m.

Report Available

Same day/1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

86606

NY State Approved

Yes