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Test ID SCL70 Scl 70 Antibodies, IgG, Serum

Useful For

Evaluating patients with signs and symptoms of scleroderma and other connective tissue diseases in whom the test for antinuclear antibodies is positive

Testing Algorithm

See Connective Tissue Disease Cascade (CTDC) in Special Instructions.

Method Name

Multiplex Flow Immunoassay

Reporting Name

Scl 70 Ab, IgG, S

Specimen Type

Serum

Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Clinical Information

Scl 70 (topoisomerase 1) is a 100-kD nuclear and nucleolar enzyme. Scl 70 antibodies are considered to be specific for scleroderma (systemic sclerosis) and are found in up to 60% of patients with this connective tissue disease. Scl 70 antibodies are more common in patients with extensive cutaneous involvement and interstitial pulmonary fibrosis, and are considered a poor prognostic sign.(1,2)

 

See Connective Tissue Disease Cascade (CTDC) in Special Instructions and Optimized Laboratory Testing for Connective Tissue Diseases in Primary Care: The Mayo Connective Tissue Diseases Cascade in Publications.

Reference Values

<1.0 U (negative)

≥1.0 U (positive)

Reference values apply to all ages.

Cautions

Testing for Scl 70 antibodies is not useful in patients without demonstrable antinuclear antibodies.

Day(s) Performed

Monday through Saturday; 4 p.m., Sunday; 11a.m.

Report Available

1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86235

NY State Approved

Yes