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HelpTest ID SECOS Secobarbital, Serum
Useful For
Monitoring secobarbital therapy
Method Name
Gas Chromatography-Mass Spectrometry (GC-MS)
Reporting Name
Secobarbital, SSpecimen Type
Serum RedContainer/Tube: Red top
Specimen Volume: 1.5 mL
Collection Instructions: Spin down within 2 hours of draw.
Forms: If not ordering electronically, complete, print, and send a Neurology Test Request Form (T732) with the specimen (http://www.mayomedicallaboratories.com/media/customer-service/forms/neurology-request-form.pdf)
Specimen Minimum Volume
0.6 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 14 days |
| Ambient | 14 days | |
| Frozen | 14 days |
Clinical Information
Secobarbital is a short-acting barbiturate with hypnotic properties used as a preanesthetic agent and in the short-term treatment of insomnia.(1,2)
Secobarbital is administered orally. The duration of its hypnotic effect is about 3 to 4 hours. The drug distributes throughout the body, with a volume of distribution (Vd) of 1.6 to 1.9 L/kg, and about 46% to 70% of a dose is bound to plasma proteins. Metabolism takes place in the liver primarily via hepatic microsomal enzymes. Secobarbital's half-life is about 15 to 40 hours (mean: 28 hours).(2,3)
Reference Values
Therapeutic concentration: 1.0-2.0 mcg/mL
Toxic concentration: >5.0 mcg/mL
Concentration at which toxicity occurs varies and should be interpreted in light of clinical situation.
Cautions
The concentration at which toxicity occurs varies; results should be interpreted in light of the clinical situation.
Day(s) Performed
Tuesday
Report Available
2 daysPerforming Laboratory
Mayo Medical Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
80345
G6043 (if appropriate)