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Test ID SHSTO Histoplasma Antibody, Serum


Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.

Secondary ID

26692

Useful For

Aiding in the diagnosis of active histoplasmosis using serum specimens

Testing Algorithm

For information see Meningitis/Encephalitis Panel Algorithm.

Method Name

Complement Fixation (CF)/Immunodiffusion (ID)

Reporting Name

Histoplasma Ab, S

Specimen Type

Serum

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Clinical Information

Histoplasma capsulatum is a soil saprophyte that grows well in soil enriched with bird droppings. The usual disease is self-limited, asymptomatic, and affects the lungs. Chronic cavitary pulmonary disease, disseminated disease, and meningitis may occur and can be fatal, especially in young children and in immunosuppressed patients.

Reference Values

MYCELIAL BY COMPLEMENT FIXATION (CF):

Negative (positives reported as titer)

 

YEAST BY CF:

Negative (positives reported as titer)

 

ANTIBODY BY IMMUNODIFFUSION:

Negative (positives reported as band present)

Cautions

Recent histoplasmosis skin tests must be avoided because the test causes a misleading rise in complement fixation titer, as well as an M precipitin band, in approximately 17% of patients having previous exposure to Histoplasma capsulatum.

 

Cross-reacting antibodies sometimes present interpretive problems in patients having blastomycosis or coccidioidomycosis.

Day(s) Performed

Monday through Friday

Report Available

2 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86698 x 3

NY State Approved

Yes