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HelpTest ID SMA Smooth Muscle Antibodies, Serum
Useful For
Evaluating patients with chronic liver disease in whom the diagnosis of chronic active autoimmune hepatitis is suspected
Method Name
Indirect Immunofluorescence
Reporting Name
Anti-Smooth Muscle AbSpecimen Type
SerumContainer/Tube:
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 0.5 mL
Forms: If not ordering electronically, complete, print, and send a General Request Form (T239) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/general-request-form.pdf).
Specimen Minimum Volume
0.2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 14 days |
Clinical Information
Sera from patients with autoimmune chronic active hepatitis contain antibodies to smooth muscle antigens that are detectable by indirect immunofluorescence on substrates that contain smooth muscle. The antibodies are predominantly of the IgG isotype.
Other diseases in this differential diagnosis group include primary biliary cirrhosis, chronic viral hepatitis, and alcoholic chronic hepatitis.
Reference Values
Negative
If positive, results are titered.
Reference values apply to all ages.
Cautions
No known false-positives or false-negatives
Day(s) Performed
Monday through Saturday; 11 a.m.
Report Available
2 daysPerforming Laboratory
Mayo Medical Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
86255-Screen
86256-Titer (if appropriate)