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HelpTest ID TMOGA Monoclonal Gammopathy, Monitoring, Serum
Ordering Guidance
Protein electrophoresis alone is not considered an adequate screen for monoclonal gammopathies. When screening a patient or establishing a first-time diagnosis for a monoclonal gammopathy, consider ordering DMOGA / Monoclonal Gammopathy, Diagnostic, Serum instead, which includes free light chain analysis.
Specimen Required
Protein electrophoresis alone is not considered an adequate screen for monoclonal gammopathies. When screening a patient or establishing a first-time diagnosis for a monoclonal gammopathy, consider ordering DMOGA / Monoclonal Gammopathy, Diagnostic, Serum instead, which includes free light chain analysis.
Specimen Required
Patient Preparation: Fasting (12 hour) preferred but not required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial.
Useful For
Monitoring patients with monoclonal gammopathies
This test is not recommended to screen or establish a first-time diagnosis for a monoclonal gammopathy.
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SPE | Protein Electrophoresis | No | Yes |
| TMAB | Therapeutic Antibody Administered? | No | Yes |
| TPE | Total Protein | Yes, (Order TP) | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IFXED | Immunofixation Delta and Epsilon, S | Yes | No |
Testing Algorithm
This test includes total protein and serum protein electrophoresis.
If a discrete electrophoresis band is not identified, the laboratory will evaluate the serum protein electrophoresis and, if necessary, perform M-protein isotype at an additional charge.
If a light chain is identified without a corresponding heavy chain during initial testing, immunofixation with IgD and IgE antisera will be performed at an additional charge.
If a history of an IgD or IgE has been previously established and no M-spike is seen on electrophoresis, immunofixation with IgD and IgE antisera will be performed at an additional charge.
Method Name
TPE: Colorimetric, Biuret
SPE: Agarose Gel Electrophoresis
Reporting Name
Monoclonal Gammopathy Monitor, SSpecimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 14 days | |
| Ambient | 7 days |
Reference Values
TOTAL PROTEIN:
≥1 year: 6.3-7.9 g/dL
Reference values have not been established for patients younger than 12 months of age.
PROTEIN ELECTROPHORESIS:
Albumin: 3.4-4.7 g/dL
Alpha 1-Globulin: 0.1-0.3 g/dL
Alpha 2-Globulin: 0.6-1.0 g/dL
Beta-Globulin: 0.7-1.2 g/dL
Gamma-Globulin: 0.6-1.6 g/dL
An interpretive comment is provided.
Reference values have not been established for patients younger than 16 years of age.
Day(s) Performed
Monday through Friday
Report Available
2 to 5 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
84155
84165
0077U (if appropriate)
86334 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| TMOGA | Monoclonal Gammopathy Monitor, S | 90991-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| TPE | Total Protein | 2885-2 |
| 602837 | Albumin | 2862-1 |
| TMAB | Therapeutic Antibody Administered? | 98855-0 |
| 602838 | Alpha-1 Globulin | 2865-4 |
| 602839 | Alpha-2 Globulin | 2868-8 |
| 602840 | Beta-Globulin | 2871-2 |
| 602841 | Gamma-Globulin | 2874-6 |
| 602842 | A/G Ratio | 44429-9 |
| 602843 | M spike | 51435-6 |
| 602844 | M spike | 35559-4 |
| 602836 | Impression | 49296-7 |