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Test ID TRAM Tramadol and Metabolite, Urine

Secondary ID

62595

Useful For

Monitoring of compliance utilizing tramadol

 

Detection and confirmation of the illicit use of tramadol

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Tramadol and Metabolite, U

Specimen Type

Urine

Container/Tube: Plastic, 10-mL urine tube (Supply T068)

Specimen Volume: 2 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.

Specimen Minimum Volume

0.10 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Clinical Information

Tramadol, a centrally-acting opioid analgesic, is utilized in the treatment of moderate to moderately severe pain. Tramadol acts as an opiate agonist through the binding of the parent drug and its O-desmethyl (M1) metabolite to mu-opioid receptors and through the weak inhibition of norepinephrine and serotonin reuptake. The active metabolite, O-desmethyltramadol, is a considerably more potent mu-opioid receptor agonist than its parent drug. In urine, approximately 30% of tramadol is excreted as unchanged drug while approximately 60% is excreted as metabolites (N- and O-desmethyltramadol). The half-life of tramadol and O-desmethyltramadol is approximately 7 hours.

Reference Values

Cutoff: <50 ng/mL

Cautions

Urine concentrations do not correlate well with serum drug levels and are not intended for therapeutic drug management.

 

Results are intended to be interpreted by a physician or health care professional. This test is not intended for use in employment-related testing.

Day(s) Performed

Tuesday, Thursday; 2nd shift

Report Available

2 days

Performing Laboratory

Mayo Medical Laboratories in New England

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80373

G0480 (if appropriate)

NY State Approved

Yes